↗ public sourceswww.addeasygroup.com/index/Animal/product.html?cid1=1&cid2=2&cid3=9· 4 studies, 4 independent/mixed
Evidence · strong
The active substance is backed by 4 studies including meta-analyses; the verdict per claim below reflects what the literature actually shows, not the brochure. Strength reflects the active substance, not the brand.
What the manufacturer claims
Free
Captured from the product page, typed and attributed — the producer’s own statements, checked against the literature below.
Physiological
Targeted butyrate delivery to the intestine, supporting gut barrier integrity
Performance
Supports intestinal maturation, villus structure and overall performance
Physiological
Helps establish a more balanced gut microbial environment
Manufacturer’s own words — not independently verified. The ledger below gives the evidence verdict for each.
Claim ↔ evidence ledger
Verdict free · receipts in Power
Each claim against the studies on the active substance, with the funding split. Open a row for the studies behind the verdict.
Claim
Verdict
Evidence & funding
PhysiologicalTargeted butyrate delivery to the intestine, supporting gut barrier integrity
Supported
2 studies · 100% indep
›
Read Barrier/morphology benefits are consistently supported by independent trials.
2019
Effects of tributyrin on growth performance, intestinal microflora and barrier function of weaned pigsIncremental tributyrin increased ADG, decreased faecal scores, and raised the jejunal/colonic Lactobacilli:E. coli ratio
Tributyrin supplementation and weight gain/intestinal gene expression in broilers during Eimeria maxima coccidiosisButyrate/tributyrin supported gut integrity and weight gain and is associated with reduced Salmonella colonisation
PerformanceSupports intestinal maturation, villus structure and overall performance
Supported
1 study · 100% indep
›
Read Growth/maturation benefit shown independently, mainly in weaned piglets and challenged broilers.
2020
Effects of tributyrin supplementation on growth, insulin, blood metabolites and gut microbiota in weaned piglets0.2% tributyrin increased BW at d40 (p=0.0006) and ADG d28-40 (p=0.046) and lowered blood urea (p=0.0026)
PhysiologicalHelps establish a more balanced gut microbial environment
Supported
1 study · 100% indep
›
Read Microbiota modulation is independently supported.
2023
Maternal tributyrin in late pregnancy/lactation improves offspring immunity, gut microbiota and diarrhoea rate (and broiler 250 mg/kg growth)250 mg/kg tributyrin improved broiler growth via blood biochemistry and caecal microbiota; maternal use improved offspring outcomes
Bottom line. Butyplus is tributyrin, a well-studied butyrate pro-drug that delivers butyrate distally without the odour of free butyrate.
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Evidence — on the active substance
Table free · full-text in Power
Why these studies The evidence for a proprietary product is the evidence for its active substance. These are the studies (meta-analyses first) behind the verdicts above, with funding labelled.
Year
Study & effect size
Funding
Type
Access
2019
Effects of tributyrin on growth performance, intestinal microflora and barrier function of weaned pigsIncremental tributyrin increased ADG, decreased faecal scores, and raised the jejunal/colonic Lactobacilli:E. coli ratio
Effects of tributyrin supplementation on growth, insulin, blood metabolites and gut microbiota in weaned piglets0.2% tributyrin increased BW at d40 (p=0.0006) and ADG d28-40 (p=0.046) and lowered blood urea (p=0.0026)
Tributyrin supplementation and weight gain/intestinal gene expression in broilers during Eimeria maxima coccidiosisButyrate/tributyrin supported gut integrity and weight gain and is associated with reduced Salmonella colonisation
Maternal tributyrin in late pregnancy/lactation improves offspring immunity, gut microbiota and diarrhoea rate (and broiler 250 mg/kg growth)250 mg/kg tributyrin improved broiler growth via blood biochemistry and caecal microbiota; maternal use improved offspring outcomes
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Analysis & tools
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The working map a maker won’t give you — built only from the evidence on this page. Nothing here is marketing.
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Open the analyst workbench
Dose benchmark, the independent-vs-sponsored split, the pooled meta-analysis effects, the contradictions and the gaps — all derived from the studies above.
Dose: label vs effective trial range vs EU max
Independence-of-evidence breakdown
Pooled meta-analysis effect sizes
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Dose benchmark
Label / recommendedNot stated on page
Effective in trials0.1-0.2% (piglets); 250-1000 mg/kg (broilers)
EU maximumAs a flavouring, governed by good practice rather than a fixed zootechnical maximum
Benefit is most consistent in weaned/challenged animals.
Butyplus is tributyrin, a well-studied butyrate pro-drug that delivers butyrate distally without the odour of free butyrate.
Independent piglet and broiler RCTs consistently show improved gut barrier, villus morphology, microbiota and growth (e.g. 0.2% raised piglet body weight and gain).
Benefits are clearest in weaned or challenged animals; in healthy, well-managed flocks the effect is smaller.
Regulatory note: tributyrin is an EU-listed flavouring compound, so its gut-health positioning is a functional claim rather than a separate authorised function.
Typical effective inclusion is ≈0.1-0.2% in piglets and ≈250-1000 mg/kg in broilers.
Where studies disagree: No material contradiction; effects are larger in young or challenged animals than in healthy, well-managed stock.
Gaps: No single tributyrin meta-analysis captured (evidence is a consistent body of RCTs). EU status sits under flavourings, not a dedicated gut-health category. No product-specific patent captured.
Manufacturer’s stated mechanism (their words): Tributyrin is a triglyceride of butyric acid that stays intact through the stomach and is gradually hydrolysed by gut lipases, releasing butyrate distally as an energy source for enterocytes, supporting epithelial barrier integrity, villus development and a balanced microbiota — without the odour of free butyrate.
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Put this beside alternatives on the same active substance (e.g. HMBi / other rumen-protected methionine), and take the data with you.
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