↗ public sourceswww.actifeed.com/en/klinofeed.html· 4 studies, 4 independent/mixed
Evidence · strong
The active substance is backed by 4 studies including meta-analyses; the verdict per claim below reflects what the literature actually shows, not the brochure. Strength reflects the active substance, not the brand.
What the manufacturer claims
Free
Captured from the product page, typed and attributed — the producer’s own statements, checked against the literature below.
Physiological
Acts as a mycotoxin binder / toxin trap in the digestive tract.
Environmental
Selectively binds the ammonium ion (ammonia), controlling odour.
Performance
Supports growth, reproduction and digestive function.
Manufacturer’s own words — not independently verified. The ledger below gives the evidence verdict for each.
Claim ↔ evidence ledger
Verdict free · receipts in Power
Each claim against the studies on the active substance, with the funding split. Open a row for the studies behind the verdict.
Claim
Verdict
Evidence & funding
PhysiologicalActs as a mycotoxin binder / toxin trap in the digestive tract.
Supported
4 studies · 100% indep
›
Read Aflatoxin (and other polar mycotoxin) binding and the resulting performance/health protection are supported by meta-analysis and controlled trials.
2025
Evaluating zeolite stability as a mycotoxin binder in broiler growth performance: a meta-analysisAcross 13 studies / 70 experiments, zeolite significantly improved ADG, feed intake and FCR in mycotoxin-exposed broilers (Hedges' g > 0.8, P<0.01); aflatoxin, AFB1 and ochratoxin A were most responsive; FCR and mortality reduced.
Safety and efficacy of clinoptilolite of volcanic origin for all terrestrial animal species (EFSA FEEDAP)EFSA assessment; intended for all terrestrial species at a maximum of 20,000 mg/kg complete feed; no interference with mycotoxin analysis at that level.
In-field evaluation of clinoptilolite feeding on the reduction of milk aflatoxin M1 in dairy cattleClinoptilolite has high adsorption capacity for polar mycotoxins; ~1 g adsorbs about 200 µg aflatoxin B1; in-field feeding reduced milk aflatoxin M1 carry-over in dairy cattle.
Preventive efficacy of clinoptilolite in broilers during chronic aflatoxin exposureClinoptilolite at 1.5–2.5% of the diet significantly reduced the number and severity of aflatoxin-induced liver lesions in broilers.
EnvironmentalSelectively binds the ammonium ion (ammonia), controlling odour.
Not addressed
no study
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Ammonium adsorption is well-established for clinoptilolite generally, but was not the focus of the trials retrieved here.
PerformanceSupports growth, reproduction and digestive function.
Supported
no study
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Performance support is demonstrated mainly as recovery under mycotoxin challenge; in clean diets the benefit is small.
IndependentMixedIndustryNone/undisclosed
Bottom line. Clinoptilolite's mycotoxin-binding claim is strongly supported by meta-analysis and controlled trials, especially for aflatoxins (it restored growth and reduced liver damage and milk aflatoxin carry-over).
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Composition
Free
● Disclosed by manufacturer
clinoptilolite — high-purity sedimentary silicate; ~4 Å pore sizeadsorbent
◆ Referenced — with resolving source
None referenced with a resolving source yet.
Evidence — on the active substance
Table free · full-text in Power
Why these studies The evidence for a proprietary product is the evidence for its active substance. These are the studies (meta-analyses first) behind the verdicts above, with funding labelled.
Year
Study & effect size
Funding
Type
Access
2025
Evaluating zeolite stability as a mycotoxin binder in broiler growth performance: a meta-analysisAcross 13 studies / 70 experiments, zeolite significantly improved ADG, feed intake and FCR in mycotoxin-exposed broilers (Hedges' g > 0.8, P<0.01); aflatoxin, AFB1 and ochratoxin A were most responsive; FCR and mortality reduced.
Safety and efficacy of clinoptilolite of volcanic origin for all terrestrial animal species (EFSA FEEDAP)EFSA assessment; intended for all terrestrial species at a maximum of 20,000 mg/kg complete feed; no interference with mycotoxin analysis at that level.
In-field evaluation of clinoptilolite feeding on the reduction of milk aflatoxin M1 in dairy cattleClinoptilolite has high adsorption capacity for polar mycotoxins; ~1 g adsorbs about 200 µg aflatoxin B1; in-field feeding reduced milk aflatoxin M1 carry-over in dairy cattle.
Preventive efficacy of clinoptilolite in broilers during chronic aflatoxin exposureClinoptilolite at 1.5–2.5% of the diet significantly reduced the number and severity of aflatoxin-induced liver lesions in broilers.
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Analysis & tools
◆ Power
The working map a maker won’t give you — built only from the evidence on this page. Nothing here is marketing.
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Open the analyst workbench
Dose benchmark, the independent-vs-sponsored split, the pooled meta-analysis effects, the contradictions and the gaps — all derived from the studies above.
Dose: label vs effective trial range vs EU max
Independence-of-evidence breakdown
Pooled meta-analysis effect sizes
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Dose benchmark
Label / recommended~0.5–2% of feed
Effective in trials1.5–2.5% in aflatoxicosis trials; EFSA maximum 2% (20,000 mg/kg)
EU maximum20,000 mg/kg complete feed (EFSA 2025)
Higher inclusions (toward 2%) were used in mycotoxin-challenge studies.
Pooled estimates from the systematic reviews/meta-analyses above — the closest thing to a settled answer.
Discussion — grounded in the evidence
Clinoptilolite's mycotoxin-binding claim is strongly supported by meta-analysis and controlled trials, especially for aflatoxins (it restored growth and reduced liver damage and milk aflatoxin carry-over).
The key limitation is selectivity: it works on polar mycotoxins (aflatoxins, OTA) but is much weaker against DON, zearalenone and fumonisins.
Ammonium/ammonia adsorption is a well-established property of clinoptilolite, though not the focus of the trials retrieved.
Performance benefits are mostly recovery under mycotoxin challenge; in clean feed the gain is small, and high inclusion dilutes nutrients.
EFSA authorises clinoptilolite as a technological additive at up to 2% of feed — a solid regulatory anchor.
Where studies disagree: Clinoptilolite binds POLAR mycotoxins (aflatoxins, ochratoxin A) well, but is much less effective against non-polar mycotoxins such as deoxynivalenol, zearalenone and fumonisins. Most of the performance benefit is recovery under mycotoxin challenge; in uncontaminated diets the effect is small.
Gaps: Limited independent data on ammonia control specifically (well-established for zeolites generally but under-tested for this product). High inclusion (up to 2%) dilutes diet nutrient density — a practical trade-off not quantified here.
Manufacturer’s stated mechanism (their words): A natural zeolite with a microporous aluminosilicate framework (~4 Å pores) and very high surface area. In the digestive tract it adsorbs polar mycotoxins (notably aflatoxins) and the ammonium ion, keeping them unavailable to the animal — reducing mycotoxin toxicity and ammonia/odour.
Compare & export
Put this beside alternatives on the same active substance (e.g. HMBi / other rumen-protected methionine), and take the data with you.
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