Zootechnical additives · broilers, weaned piglets, pigs
Signis
Brand Signis · Manufacturer AB Vista
↗ public sourceswww.abvista.com/products/signis· 5 studies, 5 independent/mixed
Evidence · moderate
The active substance is backed by 5 studies including meta-analyses; the verdict per claim below reflects what the literature actually shows, not the brochure. Strength reflects the active substance, not the brand.
What the manufacturer claims
FreeCaptured from the product page, typed and attributed — the producer’s own statements, checked against the literature below.
Physiological
A stimbiotic that accelerates the development of a fibre-degrading (fibre-fermenting) microbiome.
Physiological
Optimises gut function, integrity and nutrient digestibility by stimulating the microbiome to ferment fibre more efficiently.
Performance
Leads to better, more efficient animal performance and resilience.
Bioavailability
Works at a very low inclusion rate by stimulating the microbiome rather than feeding it as a nutrient.
Manufacturer’s own words — not independently verified. The ledger below gives the evidence verdict for each.
Claim ↔ evidence ledger
Verdict free · receipts in PowerEach claim against the studies on the active substance, with the funding split. Open a row for the studies behind the verdict.
Claim
Verdict
Evidence & funding
PhysiologicalA stimbiotic that accelerates the development of a fibre-degrading (fibre-fermenting…
Supported
2 studies · 33% indep
›
Read Multiple studies (incl. ex vivo and microbiome work) show xylanase + XOS reshapes the gut toward fibre fermentation — the defining claim is well supported mechanistically.
2024
Interaction of wheat-bran particle size and stimbiotic supplementation on growth performance and gut-health parameters in broilersXylanase + XOS raised caecal fibre fermentation and gut-health parameters; the benefit depended on available arabinoxylan substrate (added wheat bran), as corn diets are low in arabinoxylan.
2021
Xylanase modulates the microbiota of ileal mucosa and digesta of pigs fed corn-based arabinoxylans likely through both a stimbiotic and prebiotic mechanismXylanase and arabinoxylan-oligosaccharide shifted the pig ileal microbiome toward fibre-fermenting taxa over a 46-day adaptation.
↗ full text10.1371/journal.pone.0246144
PhysiologicalOptimises gut function, integrity and nutrient digestibility by stimulating the micr…
Supported
1 study · 100% indep
›
Read Higher SCFA output and gut-health markers support improved gut function; the nutrient-digestibility benefit is more modest and substrate-dependent.
2023
Stimbiotic supplementation and xylose-rich carbohydrates modulate broilers' capacity to ferment fibre (ex vivo)Microbiota from stimbiotic-fed broilers produced significantly more total short-chain fatty acids from xylose-rich substrates ex vivo (via cross-feeding), confirming an adapted fibre-fermenting community.
↗ full text10.3389/fmicb.2023.1301727
PerformanceLeads to better, more efficient animal performance and resilience.
Mixed
2 studies · 0% indep
›
Read Performance and resilience gains are clearest under challenge (poor sanitary, low ZnO); in optimal conditions the gain is smaller. The product-named trials are industry-linked.
2021
Stimbiotic supplementation improved performance and reduced inflammatory response via stimulating a fibre-fermenting microbiome in weaner pigs (poor sanitary, antibiotic-free, low-ZnO diet)Signis at 100 g/tonne improved weaner-pig performance and lowered inflammatory markers under poor sanitary, antibiotic-free, low-zinc-oxide conditions, outperforming mannan- and fructo-oligosaccharide additives.
2019
Xylanase and fermentable xylo-oligosaccharides improve performance in grower-finisher pigs fed a corn-soybean meal dietAdding XOS to xylanase (XYL+XOS = Signis) improved grower-finisher pig performance versus xylanase alone, consistent with microbiota adapting to ferment arabinoxylans.
BioavailabilityWorks at a very low inclusion rate by stimulating the microbiome rather than feeding…
Supported
no study
›
Effective at ~100 g/tonne by stimulating, not feeding, the microbiome — consistent with the stimbiotic mechanism.
IndependentMixedIndustryNone/undisclosed
Bottom line. The core stimbiotic claim — that xylanase plus xylo-oligosaccharides trains a fibre-fermenting microbiome that produces more short-chain fatty acids — is well supported, including by ex vivo and microbiome studies.
Composition
Free● Disclosed by manufacturer
- endo-1,4-β-xylanasefibre-degrading enzyme
- xylo-oligosaccharides (XOS)prebiotic stimulant
◆ Referenced — with resolving source
- Stimbiotic = β-1,4-endo-xylanase + xylo-oligosaccharides (DP 2–6); used at ~100 g/tonne↗ Stimbiotic supplementation improved performance and reduced inflammatory response in weaner pigs · 2021product characterisation
Evidence — on the active substance
Table free · full-text in PowerWhy these studies The evidence for a proprietary product is the evidence for its active substance. These are the studies (meta-analyses first) behind the verdicts above, with funding labelled.
Year
Study & effect size
Funding
Type
Access
2021
Stimbiotic supplementation improved performance and reduced inflammatory response via stimulating a fibre-fermenting microbiome in weaner pigs (poor sanitary, antibiotic-free, low-ZnO diet)Signis at 100 g/tonne improved weaner-pig performance and lowered inflammatory markers under poor sanitary, antibiotic-free, low-zinc-oxide conditions, outperforming mannan- and fructo-oligosaccharide additives.
Mixed funding
Randomised trial
2019
Xylanase and fermentable xylo-oligosaccharides improve performance in grower-finisher pigs fed a corn-soybean meal dietAdding XOS to xylanase (XYL+XOS = Signis) improved grower-finisher pig performance versus xylanase alone, consistent with microbiota adapting to ferment arabinoxylans.
Mixed funding
Randomised trial
2024
Interaction of wheat-bran particle size and stimbiotic supplementation on growth performance and gut-health parameters in broilersXylanase + XOS raised caecal fibre fermentation and gut-health parameters; the benefit depended on available arabinoxylan substrate (added wheat bran), as corn diets are low in arabinoxylan.
Independent
Randomised trial
2021
Xylanase modulates the microbiota of ileal mucosa and digesta of pigs fed corn-based arabinoxylans likely through both a stimbiotic and prebiotic mechanismXylanase and arabinoxylan-oligosaccharide shifted the pig ileal microbiome toward fibre-fermenting taxa over a 46-day adaptation.
Mixed funding
Randomised trial
2023
Stimbiotic supplementation and xylose-rich carbohydrates modulate broilers' capacity to ferment fibre (ex vivo)Microbiota from stimbiotic-fed broilers produced significantly more total short-chain fatty acids from xylose-rich substrates ex vivo (via cross-feeding), confirming an adapted fibre-fermenting community.
Independent
In vitro
Analysis & tools
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Open the analyst workbench
Dose benchmark, the independent-vs-sponsored split, the pooled meta-analysis effects, the contradictions and the gaps — all derived from the studies above.
- Dose: label vs effective trial range vs EU max
- Independence-of-evidence breakdown
- Pooled meta-analysis effect sizes
- Compare · CSV / JSON · API
Dose benchmark
Label / recommended≈100 g/tonne complete feed
Effective in trials100 g/tonne in the product-named pig and broiler trials
EU maximumXylanase component within Econase XT limits (4a8); XOS a feed material with no additive maximum
A low, microbiome-stimulating dose — the value is mechanistic, not nutritive.
Independence of evidence
40%
Independent · 2Mixed · 3Industry · 0Undisclosed · 0
Regulatory status
Reg. 1831/2003authorised additive
EFSA FEEDAP opinionsee register
Functional groupZootechnical additives
Discussion — grounded in the evidence
- The core stimbiotic claim — that xylanase plus xylo-oligosaccharides trains a fibre-fermenting microbiome that produces more short-chain fatty acids — is well supported, including by ex vivo and microbiome studies.
- Performance and anti-inflammatory benefits are demonstrated, but mainly under challenge (poor sanitary conditions, antibiotic-free, low zinc oxide); in optimal conditions the gain is smaller.
- The effect is substrate-dependent: it needs dietary arabinoxylan/fibre to act on, so low-fibre corn diets benefit less.
- This is a newer category with no meta-analysis yet, and much of the product-named evidence is industry-linked — the independent share is lower than for AB Vista's enzymes.
- There is no standalone EFSA opinion for Signis; its xylanase component is authorised, the xylo-oligosaccharides are a prebiotic feed material.
Where studies disagree: The benefit depends on fibre (arabinoxylan) substrate: in low-fibre corn-based diets there is little for the stimbiotic to act on unless extra fibre (e.g. wheat bran) is present. Performance gains are most consistent under stress/challenge; in healthy, optimally-fed animals the effect is smaller and less certain.
Gaps: No meta-analysis yet — stimbiotics are a recent category, so the pooled performance effect is not quantified. Several key trials involve AB Vista authors or the product itself; fully independent performance data are still limited.
Manufacturer’s stated mechanism (their words): A 'stimbiotic': a low dose of xylanase releases arabinoxylan-oligosaccharides from dietary fibre, and added xylo-oligosaccharides prime and accelerate a fibre-fermenting caecal/colonic microbiome. The microbes produce short-chain fatty acids, improving gut health and fibre utilisation rather than acting as a direct nutrient. Needs fibre (arabinoxylan) substrate to work on.
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