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Nutritional additives · dairy cattle, ruminants
Smartamine® M
Brand Smartamine · Manufacturer Adisseo France SAS
↗ public sourceswww.adisseo.com/eu/products/smartamine-m· 5 studies, 4 independent/mixed
Evidence · strong
The active substance is backed by 5 studies including meta-analyses; the verdict per claim below reflects what the literature actually shows, not the brochure. Strength reflects the active substance, not the brand.
What the manufacturer claims
Free
Captured from the product page, typed and attributed — the producer’s own statements, checked against the literature below.
Performance
Maximises milk yield and energy-corrected milk through enhanced secretion of milk protein and milk fat
Environmental
Balances amino acids at optimal feed cost and improves dietary nitrogen use, reducing nitrogen excretion/emissions per kg of milk
Bioavailability
Delivers methionine past the rumen (rumen-protected), correcting a limiting amino acid
Manufacturer’s own words — not independently verified. The ledger below gives the evidence verdict for each.
Claim ↔ evidence ledger
Verdict free · receipts in Power
Each claim against the studies on the active substance, with the funding split. Open a row for the studies behind the verdict.
Claim
Verdict
Evidence & funding
PerformanceMaximises milk yield and energy-corrected milk through enhanced secretion of milk pr…
Mixed
3 studies · 100% indep
›
Read Milk protein response is robustly supported by independent meta-analyses; milk-yield response is smaller and variable.
2010
Effect of rumen-protected methionine on feed intake, milk production and true milk protein: a meta-analysisRPM increased true milk protein +0.07% and +27 g/d; for Smartamine specifically, higher protein concentration with a smaller milk-yield response (+0.143 kg/d) and little fat change
Meta-analysis of lactation performance from dietary methionine sources or post-ruminal methionine infusionMilk protein yield increased from all methionine sources/infusion; Smartamine milk-fat response similar to infusion/Mepron (1.87 g fat/g MP Met)
Meta-analysis of rumen-protected methionine on milk yield and composition of dairy cowsRPM improved milk protein % (and fat %), better in high-protein diets; optimal dose 7.5-12.5 g/d; milk-yield/lactose effects were small
EnvironmentalBalances amino acids at optimal feed cost and improves dietary nitrogen use, reducin…
Not addressed
no study
›
Reduced N excretion follows from precision amino-acid balancing (avoiding excess crude protein) but is not a separately quantified endpoint here.
BioavailabilityDelivers methionine past the rumen (rumen-protected), correcting a limiting amino ac…
Supported
2 studies · 100% indep
›
Read Rumen-protected delivery and correction of the Lys:Met ratio are independently demonstrated.
2021
Effects of rumen-protected methionine (Smartamine M) on high-production dairy cows in the tropicsSmartamine M (23 g) corrected the Lys:Met ratio (3.77:1 to 2.97:1) in high-yielding cows; ~75% DL-Met, ~80% assumed bioavailability
Bottom line. Smartamine M is rumen-protected DL-methionine (≈75% DL-Met, ~80% assumed bioavailability) for dairy cows.
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Composition
Free
● Disclosed by manufacturer
DL-methionine — ~75% DL-methionine in a pH-sensitive coatingrumen-protected methionine
◆ Referenced — with resolving source
None referenced with a resolving source yet.
Evidence — on the active substance
Table free · full-text in Power
Why these studies The evidence for a proprietary product is the evidence for its active substance. These are the studies (meta-analyses first) behind the verdicts above, with funding labelled.
Year
Study & effect size
Funding
Type
Access
2010
Effect of rumen-protected methionine on feed intake, milk production and true milk protein: a meta-analysisRPM increased true milk protein +0.07% and +27 g/d; for Smartamine specifically, higher protein concentration with a smaller milk-yield response (+0.143 kg/d) and little fat change
Meta-analysis of lactation performance from dietary methionine sources or post-ruminal methionine infusionMilk protein yield increased from all methionine sources/infusion; Smartamine milk-fat response similar to infusion/Mepron (1.87 g fat/g MP Met)
Meta-analysis of rumen-protected methionine on milk yield and composition of dairy cowsRPM improved milk protein % (and fat %), better in high-protein diets; optimal dose 7.5-12.5 g/d; milk-yield/lactose effects were small
Effects of rumen-protected methionine (Smartamine M) on high-production dairy cows in the tropicsSmartamine M (23 g) corrected the Lys:Met ratio (3.77:1 to 2.97:1) in high-yielding cows; ~75% DL-Met, ~80% assumed bioavailability
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Analysis & tools
◆ Power
The working map a maker won’t give you — built only from the evidence on this page. Nothing here is marketing.
◆ Power view
Open the analyst workbench
Dose benchmark, the independent-vs-sponsored split, the pooled meta-analysis effects, the contradictions and the gaps — all derived from the studies above.
Dose: label vs effective trial range vs EU max
Independence-of-evidence breakdown
Pooled meta-analysis effect sizes
Compare · CSV / JSON · API
Dose benchmark
Label / recommended~12-15 g/day
Effective in trials7.5-23 g/d
EU maximumSet by methionine requirement, not a maximum
Meta-analytic optimum ≈7.5-12.5 g/d of metabolizable methionine.
Functional groupAmino acids, their salts and analogues
EFSA assessed this product’s protected form. Opinion ↗
Meta-analysis effects (pooled)
true milk protein (RPM, all sources) Independent+0.07 pp and +27 g/d true milk protein · n=35
milk protein % / optimal dose Independentmilk protein % improved; dose–response optimum ~7.5–12.5 g/d
Pooled estimates from the systematic reviews/meta-analyses above — the closest thing to a settled answer.
Discussion — grounded in the evidence
Smartamine M is rumen-protected DL-methionine (≈75% DL-Met, ~80% assumed bioavailability) for dairy cows.
Independent meta-analyses consistently show it raises milk protein concentration and yield, especially in methionine-limited, higher-protein diets.
The milk-yield response is modest and variable; a head-to-head meta-analysis found the competing product favoured yield while Smartamine favoured protein %.
Its environmental angle (less nitrogen excretion) follows from precise amino-acid balancing that avoids over-feeding crude protein.
Typical effective dose is ≈12-15 g/day, with a meta-analytic optimum around 7.5-12.5 g/d of metabolizable methionine.
Where studies disagree: Head-to-head meta-analysis shows the competing RPM product (Mepron) gave greater milk yield and ~2× true-milk-protein yield, while Smartamine favoured protein concentration — so 'maximises milk yield' is product-dependent; the milk-yield response to RPM overall is modest.
Gaps: No Adisseo-specific EFSA efficacy opinion captured (DL-methionine itself is authorised). Nitrogen-emission reduction is inferred from amino-acid balancing rather than directly measured here.
Manufacturer’s stated mechanism (their words): An encapsulated (rumen-protected) form of DL-methionine that escapes ruminal degradation and releases methionine in the small intestine, correcting the methionine deficiency of typical dairy diets so cows can balance amino acids and increase milk protein (and energy-corrected milk) without over-feeding crude protein.
Compare & export
Put this beside alternatives on the same active substance (e.g. HMBi / other rumen-protected methionine), and take the data with you.
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