Brand Vistacell · Manufacturer AB Vista (AB Agri Ltd)
↗ public sourceswww.abvista.com/products/vistacell· 4 studies, 2 independent/mixed
Evidence · moderate
The active substance is backed by 4 studies including meta-analyses; the verdict per claim below reflects what the literature actually shows, not the brochure. Strength reflects the active substance, not the brand.
What the manufacturer claims
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Captured from the product page, typed and attributed — the producer’s own statements, checked against the literature below.
Read Rumen-pH stabilisation supported on average; clearest in high-concentrate diets, and some trials show no pH change.
2009
Meta-analysis of Saccharomyces cerevisiae on ruminal parameters (rumen pH outcome)Rumen pH increased +0.03 on average; the benefit was larger at higher dietary concentrate and DMI
Effect of live yeast (S. cerevisiae) supplementation on rumen fermentation and metabolic profile of dairy cows in early lactation+4% daily milk yield; rumen pH 6.59 vs 6.32 control (P<0.01); higher total VFA
PerformanceImproves milk yield, feed efficiency and fibre digestion
Mixed
2 studies · 50% indep
›
Read Milk-yield/intake gains are small on average and variable between studies.
2009
Meta-analysis of the influence of Saccharomyces cerevisiae supplementation on ruminal parameters and milk production of ruminants (Desnoyers et al.)Across 157 experiments: rumen pH +0.03, rumen VFA +2.17 mM, DMI +0.44 g/kg BW, milk yield +1.2 g/kg BW, milk fat +0.05% (trend); no effect on milk protein
Feeding live yeast improved performance of mid-lactation dairy cows by altering ruminal bacterial communities and serum antioxidation/immune responses20 g/day live yeast increased DMI and yields of milk, solids, fat, protein and lactose (P<0.05) and raised rumen VFA
PhysiologicalImproves the nutrient composition of sow milk
Not addressed
no study
›
Sow-milk composition claim not addressed by the ruminant evidence captured.
IndependentMixedIndustryNone/undisclosed
Bottom line. A large meta-analysis shows live S. cerevisiae gives small but genuine average gains in dry-matter intake, milk yield and rumen pH in ruminants, with high variability.
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Evidence — on the active substance
Table free · full-text in Power
Why these studies The evidence for a proprietary product is the evidence for its active substance. These are the studies (meta-analyses first) behind the verdicts above, with funding labelled.
Year
Study & effect size
Funding
Type
Access
2009
Meta-analysis of the influence of Saccharomyces cerevisiae supplementation on ruminal parameters and milk production of ruminants (Desnoyers et al.)Across 157 experiments: rumen pH +0.03, rumen VFA +2.17 mM, DMI +0.44 g/kg BW, milk yield +1.2 g/kg BW, milk fat +0.05% (trend); no effect on milk protein
Meta-analysis of Saccharomyces cerevisiae on ruminal parameters (rumen pH outcome)Rumen pH increased +0.03 on average; the benefit was larger at higher dietary concentrate and DMI
Feeding live yeast improved performance of mid-lactation dairy cows by altering ruminal bacterial communities and serum antioxidation/immune responses20 g/day live yeast increased DMI and yields of milk, solids, fat, protein and lactose (P<0.05) and raised rumen VFA
Effect of live yeast (S. cerevisiae) supplementation on rumen fermentation and metabolic profile of dairy cows in early lactation+4% daily milk yield; rumen pH 6.59 vs 6.32 control (P<0.01); higher total VFA
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Analysis & tools
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Dose benchmark, the independent-vs-sponsored split, the pooled meta-analysis effects, the contradictions and the gaps — all derived from the studies above.
Dose: label vs effective trial range vs EU max
Independence-of-evidence breakdown
Pooled meta-analysis effect sizes
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Dose benchmark
Label / recommended~10-20 g/head/day (~1x10^10 live cells/day)
Effective in trials10^9-10^10 CFU per 100 kg body weight in trials
EU maximumset per authorised strain in the EU Register (not confirmed here)
Live-cell count (CFU) matters more than gram weight; response scales with dietary concentrate.
Pooled estimates from the systematic reviews/meta-analyses above — the closest thing to a settled answer.
Discussion — grounded in the evidence
A large meta-analysis shows live S. cerevisiae gives small but genuine average gains in dry-matter intake, milk yield and rumen pH in ruminants, with high variability.
The rumen-stabilising benefit is greatest in high-concentrate, acidosis-prone diets and smallest in forage-based diets.
A recent dairy trial confirms milk-yield and milk-component gains at 20 g/day, though it did not move rumen pH.
Much of the evidence is for the yeast class or competitor strains, not Vistacell specifically, and one key meta-analysis has an industry co-author.
The sow-milk-composition claim and the exact EU authorised strain were not verified in this pass and should be checked.
Where studies disagree: Milk and rumen-pH responses are inconsistent: several trials and reviews report no significant effect on pH or organic-matter digestibility, while others show clear gains.
Gaps: Strain-specific Vistacell trials and its EFSA/EU Register entry were not located in this pass. The sow-milk-composition claim is not supported by any captured study. Most evidence is for the S. cerevisiae class generally or for competitor strains, not Vistacell specifically.
Manufacturer’s stated mechanism (their words): Live S. cerevisiae scavenges oxygen and supports lactate-utilising and fibre-digesting rumen bacteria, helping stabilise rumen pH and improve fibre fermentation.
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Put this beside alternatives on the same active substance (e.g. HMBi / other rumen-protected methionine), and take the data with you.
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